220+
Phytocompounds isolated
for Global reference standards
220+
Registered
Patents
120+
Scientific publications in
peer viewed journals
40+
Scientists with various
domain expertise
100+
Monographs, contributed to
US & India Pharmacopeia
Natural Remedies R&D Center caters to both Animal Health Care as well as Human Health Care business and provides a platform for developing innovative products. It is well equipped with latest instruments to ensure and maintain the world class standards of health and safety, improved efficacy and increased productivity.
Levels of Checks for Clinically Proven Results
All our products have gone through various levels of checks to ensure best efficacy, safety and palatability.
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- Preclinical Study to evaluate safety and efficacy of the product
- - Efficacy studies with different prototypes
- - Safety studies (Acute Oral Toxicity study, Chronic Oral Toxicity study, Stability study, Preservative Efficacy Test (PET) Study)
- Palatability Trails to check the palatability of the product for short term & long term use
- Field Trails conducted on small number of dogs & cats in selected vet clinics across India for validating the efficacy
- - Clinical Trial done on a large scale at Mumbai Veterinary college. Conducted to document and validate all previous levels of checks in clinical cases of dogs.
Our Innovation Departments
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Phytochemistry
The Phytochemistry laboratory develops commercially viable processes for the optimum extraction of medicinal plants where active constituents (markers) are known. The plant extracts generated thereof are standardized to contain known amount(s) of biologically active constituent(s). For plants where active / markers are not known, bioactivity guided fractionations are undertaken and active / biomarkers are isolated for the purpose of standardization.
Chromatographic techniques like column, flash, MPLC, Preparative HPLC are employed for isolating constituents. The isolated single chemical entities are thoroughly characterized using the conventional spectroscopic (UV, IR, NMR & Mass spectroscopy) and chromatographic techniques.
AREAS OF COMPETENCE
- Identification of crude drugs using pharmacognostic techniques
- Isolation of markers for standardization of herbal products
- Bioactivity guided fractionations of herbs to isolate their bio-active compounds
- Development of extraction procedures for medicinal plants
- Isolation of phytochemicals of high purity for use as chromatographic reference standards
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Bioassay
In the discovery cycle, for the predictions of the effects that a drug will display, measurement of its specific functional response induced in a biological system ‘a bioassay’ is required. A bioassay is thus an essential tool for research and development. Bioassays based on the in vitro responses of enzymes or stable cell lines are commonly the assay systems of choice for this purpose. These bio-assays are rapid, reproducible, economical, sample hungry.
We have standardized and routinely perform more than 125 in-vitro assays relevant to selection and optimization of new drug candidates using specialized assay technologies based on different detection modes like Absorbance (colorimetric, ELISA), Luminescence and Fluorescence (Fluorescence Intensity, Fluorescence Polarization, Time-Resolved Fluorescence etc) in 96 and 384 well formats. The simple, rapid and cost-effective nature of bioassays facilitates screening of a large number of samples. Plants effective in in-vitro assays are developed into prototypes, which ultimately get tested in in-vivo assays.
Apart from new product development, bio-assays can be effectively be used for screening campaigns, bio-activity guided fractionation, compatibility studies, and stability studies.
AREAS OF COMPETENCE
- Development of in-vitro pharmacological methods for drug evaluation.
- Biological standardization of herbal products.
- Application of bioassay methods to stability testing and testing combinational effect of herbal extracts.
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Microbiology
This laboratory is specialized to conduct microbiological quality control and antimicrobial screening of herbal products. Various analytical procedures in this laboratory are tailor made to suit herbal products and are in accordance with USP method.
Areas of Competence
- Analysis of herbal products for microbiological contamination.
- Determination of MIC.
- Determination of MBC.
- Immersion bio-autography for identification of antibacterial compounds.
- Preservative efficacy testing.
- Development of preservative systems.
- Testing of plant extracts and their derivatives for combinational effects to determine synergy, antagonism and additivity.
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Pharmacology & Toxicology
Profile
The Department is comprised of three major divisions: In vitro, In vivo and Clinical Pharmacology. Presently, the department includes a team of competent scientists from various disciplines like pharmacology, biochemistry, and other allied life sciences. The department is committed to the development of a strong herbal research environment within and between various other divisions. The divisions are well equipped with sophisticated instruments for in vitro pharmacological assays and a central animal facility registered under Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA) for efficacy and toxicity studies.
Mandate
Evaluation of herbs for therapeutic use and safety assessment of mono- and polyherbal formulations are the core areas of focus. The team is engaged in evaluating a range of products for veterinary and human health care, to cater to the needs of livestock and human segments.
Areas of Recent Focus
- Inflammation
- Pain
- Diabetes
- Weight Management/Obesity
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Analytical & Instrumentation
Instrumental analysis is an integral part of Quality Assurance. This laboratory is equipped with:
The Department is comprised of three major divisions: In vitro, In vivo and Clinical Pharmacology. Presently, the department includes a team of competent scientists from various disciplines like pharmacology, biochemistry, and other allied life sciences. The department is committed to the development of a strong herbal research environment within and between various other divisions. The divisions are well equipped with sophisticated instruments for in vitro pharmacological assays and a central animal facility registered under Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA) for efficacy and toxicity studies.
- UV-VIS Spectrophotometer.
- High Performance Liquid Chromatograph (HPLC), Preparative & Analytical.
- Gas Chromatograph.
- HPTCL
- FTIR
We also have the access to Mass spectrometer, LC-MS, NMR, AAS, ICP-MS etc:
This group is already engaged in development of analytical monographs for more than one dozen Indian Medicinal Plants for the forthcoming Indian Pharmacopoeia along with Central Indian Pharmacopoeia Laboratory (C I P L) (Govt. of India), Ghaziabad. This lab routinely uses specific and non-specific bio-assays wherever possible in order to achieve bio-standardization.
Mandate
Evaluation of herbs for therapeutic use and safety assessment of mono- and polyherbal formulations are the core areas of focus. The team is engaged in evaluating a range of products for veterinary and human health care, to cater to the needs of livestock and human segments.
AREAS OF COMPETENCE
- Development of meaningful quality assessment parameters for plants where actives/bioactives are not known.
- Quantitative determination of known active principles, biomarkers and marker components in raw material, extracts, essential Oils using HPLC, HPTLC, GC etc.
- Development and validation of analytical procedures.
- Residual analysis (Heavy metals, Mycotoxins, Pesticides & Solvents).
- Stability testing.
- Standardization of herbal products.
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Formulation & Development
Formulation and Development is one of the key department in R&D. The main objective of this department is to develop new formulations in different dosage forms for Human and Veterinary use. The lab is equipped with modern infrastructure for carrying out formulation studies. The lab has developed first herbal aerosol spray for veterinary use in India.
AREAS OF COMPETENCE
- Development of appropriate dosage forms which are stable and convenient to administer.
- Preformulation studies to understand the nature of actives from formulation angle.
- Stability studies of finished formulations for establishing the shelf life.
- Conducting scale up trials to produce standard operating procedures for commercial production.
- End to end management of new product innovation in collaboration with other labs
- Application of best in practices for new product development ( example: Stage Gate Approach)
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Agronomy
As a manufacturer of herbal products, we consume more than 500 tones of crude drug / annum. This requirement of crude drugs is almost wholly fulfilled by collections from the wild / forests. But it is not possible to derive all this material from the wild, because the population of wild medicinal plants is growing thinner day by day due to over exploitation and indiscriminate deforestation. Moreover, because of insufficient raw material ( poor availability ), the price of material shoots up. These are thus valid reasons for cultivating medicinal plants.
We undertake Contract Farming of selected Indian medicinal plants through interested farmers and offer cent percent buy back. Our agriculture farming is stipulated under strictly defined conditions as are specific for each plant. We provide the planting material and complete cultivation plan to farmers and to supervise the proper implementation of plan we have groomed a team of Agriculture Graduates. Our agronomy team has covered approximately 1500 acres of land under contract farming in South India through buy back agreements.
Through contract farming we have done good R&D work to formulate Good Agricultural Practices, which includes proper selection and identification, propagation methods, cultivation techniques, harvesting, step-wise quality control of raw material up to processing stage, post-harvest treatment, storage and safety.
We provide buy-back guarantee to farmers who can grow medicinal plants of our interest
For more details contact: agronomy@naturalremedy.com
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Research Papers
1995
- D’Souza P, Rao A, Amit A (1995) Stability of anti-bacterial activity of Himax.Indian Journal of Indigenous Medicine. 16: 135 – 137.
- Vijayalakshmi K (1999) Cultivation of Medicinal Plants & Contract Farming. (Medicinal & Aromatic Plants). Plant Hort Tech 39-41.
- Prashanth D, John S (1999) Antibacterial activity of Peganum harmala. Fitoterapia 70: 438 - 439.
- Prashanth D, Asha MK, Amit A (2001) Antibacterial activity of Punica granatum. Fitoterapia 72: 171-173.
- Prashanth D, Padmaja R, Samiulla DS (2001) Effect of certain plant extracts on alpha-amylase activity. Fitoterapia 72: 179-181.
- Samiulla DS, Prashanth D, Amit A (2001) Mast cell stabilizing activity of Bacopa monnieri. Fitoterapia 72: 284-285.
- Prashanth D, Asha MK, Amit A, Padmaja R (2001) Anthelmintic Activity of Butea monosperma. Fitoterapia 72: 421-422.
- Asha MK, Prashanth D, Padmaja R, Amit A, Murali B (2001) Anthelmintic activity of essential oil of Ocimum sanctum & eugenol. Fitoterapia 72: 669-670.
- Prashanth D, Amit A, Samiulla DS, Asha MK, Padmaja R (2001) Alpha -glucosidase inhibitory activity of Mangifera indica. Fitoterapia 72: 686-688.
- Samiulla DS, Prashanth D, Amit A, Venkataraman BV (2001) Trypsin inhibitory activity of Punica granatum. Linn Journal of Natural Remedies 1: 73-74.
- Samiulla DS, Harish MS (2001) Comparative effect of NR-AG-I (Stonil) and NR-AG-II (Stonil) (polyherbal formulations) against gentamicin-induced nephrotoxicity in rats. Journal of Natural Remedies. 1: 42 - 44.
- Murali B, Amit A, Anand MS, Dinesh TK, Samiulla DS (2001), An improved HPLC method for estimation of phyllanthin and hypophyllanthin in Phyllanthus amarus. Journal of Natural Remedies. 1: 55-59.
- Arun PC, Murali B, Anand MS, Deepak M (2001) Screening of pyrrolizidine alkaloids in some herbal drugs. Journal of Natural Remedies. 1: 67-69.
- Nadig PD, Nanjraje U, Amit A (2001) In vitro uterotonic activity of Involon. study Journal of Natural Remedies 1: 158 – 159.
- Rajeshwari NR, Pande CB, Kiran A (2001) Effect of Zeestress on broiler performance-a study Journal of Natural Remedies. 1(1): 70-72.
- Prashanth D, Deepak M, Padmaja R, Sandhya KV, Anjana M, Arun PC, Amit A (2002) Brine shrimp lethality assay of Bacopa monnieri. Phytotherapy Research 16: 197 - 198.
- Padmaja R, Arun PC, Prashanth D, Deepak M, Amit A, Anjana M (2002) Brine shrimp lethality bioassay of selected Indian Medicinal plants. Fitoterapia 73: 508-510.
- Yogisha S, Samiulla DS, Prashanth D, Padmaja R, Amit A (2002). Trypsin inhibitory activity of Lawsonia inermis. Fitoterapia73: 690-691.
- Deepak M, Dipankar G, Prashanth D, Asha MK, Amit A, Venkataraman BV (2002) Tribulosin and Alpha-sitosterol – D-glucoside, the anthelmintic principles of Tribulus terrestris. Phytomedicine 9: 753-756.
- Sudha S, Kumaresan S, Amit A, David J, Venkatraman BV (2002) Anti-convalsant activity of different extracts of Centella asiatica and Bacopa monnieri in animals. Journal of Natural Remedies. 2: 33-41.
- Murali B, Amit A, Anand S, Venkataraman BV (2002) An HPLC method for simultaneous estimation of Psoralen, Bakuchicin and Bakuchiol in Psoralea corylifolia. Journal of Natural Remedies. 2: 76-79.
- Prashanth D, Asha MK, Balaji G, Biju J, Yogisha S, Amit A (2002) Stability of antimicrobial activity of Wisprec – a cross sectional study. Journal of Natural Remedies 2: 96 – 98.
- Ashok K, Amit A, Sujatha M, Murali B, Anand MS (2002) Effect of aging on andrographolide content in Andrographis paniculata Journal of Natural Remedies 2 : 179-181.
- Murali B, Amit A, Anand MS, Samiulla DS (2002) Estimation of wedelolactone and demethylwedelolactone in Eclipta alba Hassk by improved chromatograhic analysis. Journal of Natural Remedies 2: 99 – 101.
- Samiulla DS, Deepak M, Yogisha S, Arun PC, Keerthi AM, Prashanth D, Amit A, Venkataraman BV. (2003) "Trypsin inhibitory effect of Wedelolactone & Demethylwedelolactone". Phytotherapy Research 17(4): 420-421.
- Prashanth D, Amit A, Yogisha S, Padmaja R. (2003) "Demonstration of biological standardization of selected herbal extracts”. Journal of Natural Remedies, 3/2: 166-173.
- Asha MK, Prashanth D, Amit A, Rama MB, Murali B. (2003) "Geraniol, the putative anthelmintic principle of Cymbopogon martinii", Phytotherapy Research 17(8): 957.
- Vyjayanthi G, Subhashchandra S, Saxena VS, Nadig PD, Venkateshwarlu K, Serene A, Sathyan S, Bagchi D, Kulkarni C, (2003) “Randomized, double-blind, placebo-controlled trial of Aller-7 in patients with allergic rhinitis, Research Communications in Pharmacology and Toxicology Vol. 8, Issue. 1-2,. Emerging drugs Vol II, IV 15-IV 24.
- Amit A, Saxena VS, Pratibha N, Bagchi M, Bagchi D, Stohs SJ. (2003). “Safety of a novel botanical extract formula for ameliorating Allergic rhinitis”, Toxicology Mechanisms and Methods, 13(4), Pg. 253-261.
- Amit A, Saxena VS, Pratibha N, D’Souza P, Bagchi M, Bagchi D, Stohs SJ. (2003) “Mast cell stabilization, Lipoxygenase inhibition, hyaluronidase inhibition, anti-histaminic and anti-spasmodic activities of Aller-7, a novel botanical formulation for Allergic rhinitis”. Drugs Under Experimental and Clinical Research. XXIX (3) Pg. 107-115.
- D’Souza P, Amit A, Saxena VS, Bagchi D, Bagchi M, Stohs SJ (2004) “Antioxidant properties of Aller-7, a novel polyherbal formulation for allergic rhinitis”. Drugs Under Experimental and Clinical Research. XXX (3) Pg.99-109
- Saxena VS, Venkateshwarlu K, Nadig P, Barbhaiya HC, Bhatia N, Borkar DM, Gill RS, Jain RK, Katiyar SK, Nagendra Prasad KV, Nalinesha KM, Nasiruddin K, Rishi JP, Roy Chowdhury J, Saharia PS, Thomas B, Bagchi D. (2004) “Multi-Center clinical trials on a novel polyherbal formulation in allergic rhinitis”. International Journal of Clinical Pharmacology Research, XXXIV(2/3) 79-94
- Pratibha N, Saxena VS, Amit A, D’Souza P, Bagchi D, Bagchi M (2004) “Anti-inflammatory activities of Aller-7, a novel polyherbal formulation for allergic rhinitis”. International Journal of Tissue Reactions. XXVI(1/2) 43-51
- Deepak M, Amit A, (2004) “The need for establishing identities of ‘bacoside A and B’ the putative major bioactive saponins of Indian medicinal plants Bacopa monnieri” published in Phytomedicine 11(2-3): 264-268
- Deepak, G.K. Sangli, P.C.Arun and Amit A. (2005) “Quantitative Determination of the Major Saponin Mixture Bacoside A in Bacopa monnieri by HPLC” Phytochemical Analysis 16 : 24-29.
- Amit A, Joshua AJ, Saxena VS, Bagchi M, Bagchi D (2005) “Safety evaluation of a novel polyherbal formulation for ameliorating allergic rhinitis” Part II. Toxicology Mechanisms & Methods 15:193-204.
- Sudha S, Bindu R, Joyce G, Amit A, Venkataraman BV (2005) “Pharmacological interaction of Centella asiatica and Bacopa monnieri with antiepileptic drugs – an experimental study in rats” Journal of Natural Remedies. Vol 5: 63-69.
- Nadig PD, Lakshmi S, (2005) “Study of anti-tussive activity of Ocimum sanctum in guinea pigs” Indian Journal of Physiology and Pharmacology 49(2): 243-245.
- Joshua AJ, Venkateshwarlu K, Anuradha K, Amit A (2006) “Current scenario in discovery and development of phytomedicines.” Journal of Indian Veterinary Association 4(2): 34-36.
- Damodaran A, Wasim P, Joshua AJ, Amit A (2006) “Prospects and challenges in development of herbal medicines.” Journal of Indian Veterinary Association 4 (2): 39-41.
- Singh SK, Khanam S, Shivananda BG, Amit A, Shivananda TN (2006) “Genetic variations in gymnemic acid content of Gymnema sylvestre leaves”, Biomed 1(1): 26-28.
- Singh SK, Khanam S, Shivananda BG, Amit A, Harish GU, Shivananda TN (2006) “Effect of age leaf on gymnemic acid content Gymnema sylvestre (R. Br) leaves” Biomed July-Sept, 1 (2): 159-160.
- Satish H, Dang R, Shivananda BG, Devi K, Rajesh MS, Deepak M, Shivananda TN (2006), “Antiurolithiatic herbal drugs-A review” Biomed July-Sept., 1 (2): 95-119.
- Schauss AG, Wu X, Prior RL, Ou B, Huang D, Owens J, Amit A, Jensen G, Hart AN, Shanbrom E (2006) “Antioxidant capacity and other bioactivities of the freeze-dried Amazonian palm berry, Euterpe oleraceae Mart. (Acai)” Journal of Agricultural And Food Chemistry 54(22): 8604-8610.
- Joshua AJ, Vinod DR, Pravina K, Suja RS, Goudar KS, Pande CB, Amit A Lipotropic activity of Natcol, a polyherbal formulation in albino wistar rats. Journal of Natural Remedies 6(2): 174-180.
- Vinutha B, Prashanth D, Salma K, Sreeja SL, Pratiti D, Padmaja R, Radhika S, Amit A, Venkateshwarlu K, Deepak M, (2007) “Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity”, Journal of Ethnopharmacology 109: 359-363.
- Kasture SB, Kasture VS, Joshua AJ, Damodaran A, Amit A, (2007) “Nootropic activity of BacoMind™ an enriched photochemical composition from Bacopa monnieri” Journal of Natural Remedies 7(1): 166-173.
- Nikhil S, Sudha S, Aruna B, Amarjeeth R, Guido S, Amit A, (2007) “Preliminary evaluation of different components of Bacopa monnieri for laxative effect.” Journal of Natural Remedies 7(1): 174-182.
- Pravina K, Ravindra KR, Goudar KS, Vinod DR, Joshua AJ, Wasim P, Venkateshwarlu K, Saxena VS, Amit A (2007) “Safety evaluation of BacoMind™ in healthy volunteers: A phase I study” Phytomedicine 14: 301-308.
- Allan JJ, Damodaran A, Desmukh NS, Goudar KS, Amit A, (2007) “Safety evaluation of astandardized phytochemical composition extracted from Bacopa monnieri in Sprague-dawley rats” Food and Chemical Toxicology 45: 1928-1937.
- Deb DD, Kapoor P, Dighe RP, Padmaja R, Anand MS, D’Souza P, Deepak M, Murali B, Amit A (2008) In vitro safety evaluation and anticlastogenic effect of BacoMind™ on human lymphocytes. Biomedical And Environmental Sciences 21: 7-23.
- Usha PD, Wasim P, Joshua AJ, Geetarani P, Murali B, Mayachari AS, Venkateshwarlu K, Saxena VS, Deepak M, Amit A (2008) BacoMind™: A cognitive enhancer in children requiring individual education programme. Journal of Pharmacology and Toxicology 3(4): 302-310.
- D’Souza PCG, Ally N, Amit A, Padmaja R, Das M, Sarma D, (2008) Demonstration of LanthaScreen™ TR-FRET-based nuclear receptor coactivator recruitment assay using PHERA star a multi-detection HTS microplate reader. Indian Journal of Pharmacology, 40(2): 89-90.
- Barbhaiya HC, Desai RP, Saxena VS, Pravina K, Wasim P, Geetharani P, Allan JJ, Venkateshwarlu K, Amit A, (2008) Efficacy and tolerability of BacoMind on memory improvement in elderly participants-A double blind placebo controlled study. Journal of Pharmacology and Toxicology, 3(6): 425-434.
- Nigam V, Paarakh PM, Murali B, Amit A, (2008) A HPLC method for the quantitative estimation of guggulsterone-E and guggulsterone-Z in Commiphora mukul (Hook. Et. Stocks) Engl. Gum resin. Pharmakine, 1(1): 25-30.
- Joshua AJ, Vijayabalaji V, Goudar KS, Sameera N, Amit A. (2008) Safety assessment of some herbal formulations on acute exposure in rats. Indian Journal of Natural Products 24(3), 10-16.
- Joshua AJ, Goudar KS, Damodaran A, Sameera N, Amit A. (2008) Acute oral toxicity evaluation of some polyherbal formulations in albino Wistar rats. International Journal of Pharmacology 4(5): 388-392.
- Sumanth M, (2009), Study of antistress activity of NR-A2 in active anaphylaxis-induced allergic rats, Asian Journal of Experimental Sciences 23(1): 317-320.
- Sumanth M, Yavagal M, (2009) “Preclinical screening of NR-A2 for antistress, anti allergic properties”. Journal of Natural Remedies. 9(1):103-110
- Chandeasekaran CV, Thiyagarajan P, Sundarajan K, Goudar KS, Deepak M, Murali B, Allan JJ, Agarwal A, (2009) Evaluation of the genotoxic potential and acute oral toxicity of standardized extract of Andrographis paniculata (KalmColdTM) Food and Chemical Toxicology 47: 1892–1902.
- Joshua AJ, Pore MP, Deepak M, Murali B, Anand MS, Amit A, (2009), Reproductive and Fertility Effects of an Extract of Andrographis paniculata in Male Wistar Rats International Journal of Toxicology, 28,(4): 308-317 .
- Kasture S, Vinci S, Ibha F, Puddu A, Marongiu M, Murali B, Pisanu A, Lecca D, Zernig G, Acquas E (2009) Withania somnifera prevents morphine withdrawal-induced decrease in spine density in nucleus accumbens shell of rats: A confocal laser scanning microscopy study. Neurotoxicity Research 16: 343–355.
- John S, Nikhil S, Yaswanth J, Bhaskar A, Amit A, Sudha S (2009)Analgesic property of different extracts of Curcuma longa (Linn): an experimental study in animals, Journal of Natural Remedies 9(1): 116-120.
- Chandrasekaran CV, Mathuram LN, Prabhu D, Bhatnagar U, (2009) Tinospora cordifolia, a safety evaluation. Toxicology in Vitro 23 :1220–1226
- Dey S, Deepak M, Setty M, D’Souza P, Amit A, Sangli GK, (2009), Bioactive caffeic acid esters from Glycyrrhiza glabra. Natural Product Research, 23(18): 1657-1663.
- Saxena RC, Singh R, Kumar P, Yadav SC, Negi MPS, Saxena VS, Joshua AJ, Vijayabalaji V, Goudar KS, Venkateshwarlu K, Amit A (2010) A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold™) inpatients with uncomplicated upper respiratory tract infection, Phytomedicine 17,178–185.
- Mukherjee M, Bhaskaran N, Srinath R, Shivaprasad HN, Allan JJ, Shekhar D, Amit A (2010), Anit-ulcer and antioxidant activity of GutGard™. Indian Journal of Experimental Biology, 48(3): 269-274.
- Joshua AJ, Goudar KS, Sameera N, Kumar GP, Murali B, Dinakar N, Amit A (2010) Safety Assessment of Herbal Formulations, Rumbion™ and Tyrel™ in Albino Wistar Rats. American Journal of Pharmacology and Toxicology 5(1): 42-47.
- Bhanumathy M, Harish MS, Shivaprasad HN, Sushma G, (2010), Nootropic activity of Celastrus paniculata seed, Pharmaceutical Biology, 48(3): 324-327.
- Chandrasekaran CV, Gupta A, Amit A, (2010) Effect of an extract of Andrographis paniculata leaves on inflammatory and allergic mediators in vitroJournal of Ethnopharmacology, 129: 203-207.
- Vijayabalaji V, Allan JJ, Kumar GP, Murali B, Suryanaraya ML, Amit A, (2010), Evaluation of safety of Naturaliv™ liquid and Zist™ liquid on acute oral exposure in rats, Journal of Pharmacology and Toxicology, 5(8): 450-459.
- Agarwal A, Allan JJ, (2010), Antifertility effects of herbs: Need for responsible reporting. Journal of Ayurveda & Integrative Medicine, 1(2): 129-131.
- Chandrasekaran CV, Sundarajan K, David K, Amit A, (2010), In vitro efficacy and safety of poly-herbal formulation, Toxicology In Vitro, 24(3): 885-897.
- Soosamma J, Madhavi T, Bincy R, Dang R, Deepak M, (2010), New compounds from the stem bark of Crataeva nurvala, Indian Journal of Natural Products, 26(3), 16-19.
- Mishra NK, Allan JJ, (2010), Evaluation of anti-inflammatory activity and potency of herbal formulation consists of different proportions of Curcuma longa and Boswellia serrata by using Cotton pellet granuloma and xylene induced mice ear edema model. International Journal of PharmTech Reseach, 2(3): 1855-1860.
- Morgan Annette, Stevens J, (2010), Does Bacopa monnieri improve memory performance in older persons? results of randomized, placebo-controlled double-blind trial. The Journal of Alternative And Complimentary Medicine, 16(7): 753-759.